Pseudomonas syringae pv. tomato DC3000: a model pathogen for probing disease susceptibility and hormone signaling in plants

Annu Rev Phytopathol. 2013;51:473-98. doi: 10.1146/annurev-phyto-082712-102321. Epub 2013 May 31.

Abstract

Since the early 1980s, various strains of the gram-negative bacterial pathogen Pseudomonas syringae have been used as models for understanding plant-bacterial interactions. In 1991, a P. syringae pathovar tomato (Pst) strain, DC3000, was reported to infect not only its natural host tomato but also Arabidopsis in the laboratory, a finding that spurred intensive efforts in the subsequent two decades to characterize the molecular mechanisms by which this strain causes disease in plants. Genomic analysis shows that Pst DC3000 carries a large repertoire of potential virulence factors, including proteinaceous effectors that are secreted through the type III secretion system and a polyketide phytotoxin called coronatine, which structurally mimics the plant hormone jasmonate (JA). Study of Pst DC3000 pathogenesis has not only provided several conceptual advances in understanding how a bacterial pathogen employs type III effectors to suppress plant immune responses and promote disease susceptibility but has also facilitated the discovery of the immune function of stomata and key components of JA signaling in plants. The concepts derived from the study of Pst DC3000 pathogenesis may prove useful in understanding pathogenesis mechanisms of other plant pathogens.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Amino Acids
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Disease Susceptibility*
  • Host-Pathogen Interactions
  • Indenes
  • Models, Biological
  • Plant Diseases / immunology
  • Plant Diseases / microbiology*
  • Plant Growth Regulators / metabolism*
  • Plant Immunity
  • Plant Stomata / immunology
  • Plant Stomata / microbiology
  • Plants / immunology
  • Plants / microbiology*
  • Pseudomonas syringae / genetics
  • Pseudomonas syringae / pathogenicity*
  • Pseudomonas syringae / physiology
  • Signal Transduction
  • Virulence

Substances

  • Amino Acids
  • Bacterial Proteins
  • Indenes
  • Plant Growth Regulators
  • coronatine