An evidence-based systematic review of kratom (Mitragyna speciosa) by the Natural Standard Research Collaboration

J Diet Suppl. 2013 Jun;10(2):152-70. doi: 10.3109/19390211.2013.793541.

Abstract

An evidence-based systematic review of kratom (Mitragyna speciosa) by the Natural Standard Research Collaboration consolidates the safety and efficacy data available in the scientific literature using a validated, reproducible grading rationale. This article includes written and statistical analysis of clinical trials, plus a compilation of expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Analgesics / adverse effects
  • Analgesics / chemistry
  • Analgesics / pharmacology
  • Analgesics / therapeutic use*
  • Animals
  • Antitussive Agents / adverse effects
  • Antitussive Agents / chemistry
  • Antitussive Agents / pharmacology
  • Antitussive Agents / therapeutic use
  • Dietary Supplements* / adverse effects
  • Ethnopharmacology
  • Evidence-Based Medicine*
  • Herb-Drug Interactions
  • Humans
  • Mitragyna / adverse effects
  • Mitragyna / chemistry*
  • Plant Extracts / adverse effects
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Plant Leaves / adverse effects
  • Plant Leaves / chemistry*
  • Psychotropic Drugs / adverse effects
  • Psychotropic Drugs / chemistry
  • Psychotropic Drugs / pharmacology
  • Psychotropic Drugs / therapeutic use
  • Secologanin Tryptamine Alkaloids / analysis

Substances

  • Analgesics
  • Antitussive Agents
  • Plant Extracts
  • Psychotropic Drugs
  • Secologanin Tryptamine Alkaloids
  • mitragynine