IL-22 secreting CD4+ T cells in the patients with neuromyelitis optica and multiple sclerosis

J Neuroimmunol. 2013 Aug 15;261(1-2):87-91. doi: 10.1016/j.jneuroim.2013.04.021. Epub 2013 May 28.


Interleukin (IL)-22 secreting CD4(+) T (Th22) cells and IL-22 are involved in the pathogenesis of autoimmune disease, but their role in neuromyelitis optica (NMO) and multiple sclerosis (MS) is unclear. We measured the proportion of Th22, Th17, CD4(+)IL-22(+)IL-17A(+) T cells and serum IL-22 in NMO and MS patients. The proportion of Th22 cells, Th17 cells and serum IL-22 were increased in patients with NMO and MS. Our findings suggest that increased Th22 cells may play an important role in the pathogenesis of NMO and MS.

Keywords: IL-22; IL-22 secreting CD4+ T cells; MS; NMO; Th22 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / metabolism*
  • CD4-Positive T-Lymphocytes / pathology
  • Female
  • Humans
  • Interleukins / blood*
  • Interleukins / metabolism*
  • Male
  • Middle Aged
  • Multiple Sclerosis / diagnosis
  • Multiple Sclerosis / etiology
  • Multiple Sclerosis / pathology*
  • Neuromyelitis Optica / diagnosis
  • Neuromyelitis Optica / etiology
  • Neuromyelitis Optica / pathology*
  • Young Adult


  • Biomarkers
  • Interleukins
  • interleukin-22