Chronic kidney disease: global dimension and perspectives

Lancet. 2013 Jul 20;382(9888):260-72. doi: 10.1016/S0140-6736(13)60687-X. Epub 2013 May 31.


Chronic kidney disease is defined as a reduced glomerular filtration rate, increased urinary albumin excretion, or both, and is an increasing public health issue. Prevalence is estimated to be 8-16% worldwide. Complications include increased all-cause and cardiovascular mortality, kidney-disease progression, acute kidney injury, cognitive decline, anaemia, mineral and bone disorders, and fractures. Worldwide, diabetes mellitus is the most common cause of chronic kidney disease, but in some regions other causes, such as herbal and environmental toxins, are more common. The poorest populations are at the highest risk. Screening and intervention can prevent chronic kidney disease, and where management strategies have been implemented the incidence of end-stage kidney disease has been reduced. Awareness of the disorder, however, remains low in many communities and among many physicians. Strategies to reduce burden and costs related to chronic kidney disease need to be included in national programmes for non-communicable diseases.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / complications
  • Acute Kidney Injury / mortality
  • Aristolochic Acids / adverse effects
  • Awareness
  • Balkan Nephropathy / etiology
  • Balkan Nephropathy / mortality
  • Cardiovascular Diseases / complications
  • Cardiovascular Diseases / mortality
  • Cost-Benefit Analysis
  • Early Diagnosis
  • Global Health
  • HIV Infections / complications
  • Health Knowledge, Attitudes, Practice
  • Humans
  • Incidence
  • Plant Preparations / adverse effects
  • Prevalence
  • Renal Insufficiency, Chronic / etiology
  • Renal Insufficiency, Chronic / mortality*
  • Renal Insufficiency, Chronic / prevention & control
  • Residence Characteristics
  • Risk Factors
  • Socioeconomic Factors
  • Water Microbiology
  • Water Supply


  • Aristolochic Acids
  • Plant Preparations
  • aristolic acid