Control of metastatic progression by microRNA regulatory networks

Nat Cell Biol. 2013 Jun;15(6):546-54. doi: 10.1038/ncb2769.


Aberrant microRNA (miRNA) expression is a defining feature of human malignancy. Specific miRNAs have been identified as promoters or suppressors of metastatic progression. miRNAs control metastasis through divergent or convergent regulation of metastatic gene pathways. Some miRNA regulatory networks govern cell-autonomous cancer phenotypes, whereas others modulate the cell-extrinsic composition of the metastatic microenvironment. The use of small RNAs as probes into the molecular and cellular underpinnings of metastasis holds promise for the identification of candidate genes for potential therapeutic intervention.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Disease Progression
  • Gene Expression Regulation, Neoplastic
  • Humans
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism*
  • Neoplasm Metastasis / genetics*
  • Neoplasms / genetics*
  • Regulatory Sequences, Ribonucleic Acid / genetics*
  • Signal Transduction


  • MicroRNAs
  • Regulatory Sequences, Ribonucleic Acid