The effect of topical cyclosporine 0.05% on dry eye after cataract surgery

Korean J Ophthalmol. 2013 Jun;27(3):167-71. doi: 10.3341/kjo.2013.27.3.167. Epub 2013 Apr 8.


Purpose: To evaluate the effectiveness of cyclosporine 0.05% for dry eye after cataract surgery.

Methods: Thirty-two newly diagnosed patients with dry eye syndrome 1 week after cataract surgery received a twice-daily treatment of cyclosporine 0.05% for one eye and normal saline 0.9% for the other. Disease severity was measured at 2 weeks, 1 month, 2 months, and 3 months by Schirmer test I (ST-I), tear film break-up time (tBUT), corneal temperature and dry eye symptom questionnaire (Ocular Surface Disease Index).

Results: Both groups increased in ST-I and tBUT over time. ST-I in the cyclosporine 0.05% group showed a significant increase at 3 months and tBUT in the cyclosporine 0.05% group showed an increase at 2 and 3 months. The dry eye symptom score was significantly reduced in the cyclosporine 0.05% group.

Conclusions: Cyclosporine 0.05% can also be an effective treatment for dry eye after cataract surgery.

Keywords: Cataract surgery; Cyclosporine; Dry eye syndromes.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cataract Extraction*
  • Cyclosporine / administration & dosage*
  • Dry Eye Syndromes / drug therapy*
  • Female
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Male
  • Middle Aged
  • Ophthalmic Solutions / administration & dosage*
  • Postoperative Complications / drug therapy*
  • Treatment Outcome


  • Immunosuppressive Agents
  • Ophthalmic Solutions
  • Cyclosporine