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. 2012 Jun;9(2):99-106.

Depression Remission After Six Months of Collaborative Care Management: Role of Initial Severity of Depression in Outcome

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Free PMC article

Depression Remission After Six Months of Collaborative Care Management: Role of Initial Severity of Depression in Outcome

Kurt B Angstman et al. Ment Health Fam Med. .
Free PMC article

Abstract

Aim The impact of initial severity of depression on the rate of remission has not been well studied. The hypothesis for this study was that increased depression severity would have an inverse relationship on clinical remission at six months while in collaborative care management. Participants The study cohort was 1128 primary care patients from a south-eastern Minnesota practice and was a longitudinal retrospective chart review analysis. Results Clinical remission at six months was less likely in the severe depression group at 29.6% compared with 36.9% in the moderately severe group and 45.6% in the moderate depression group (P < 0.001). Multivariate analysis of a sub-group demonstrated that increased initial anxiety symptoms (odds ratio [OR] 0.9645, 95% confidence interval [CI] 0.9345-0.9954, P = 0.0248) and an abnormal screening for bipolar disorder (OR 0.4856, 95% CI 0.2659-0.8868, P = 0.0187) predicted not achieving remission at six months. A patient with severe depression was significantly less likely to achieve remission at six months (OR 0.6040, 95% CI 0.3803-0.9592, P = 0.0327) compared with moderate depression, but not moderately severe depression (P = 0.2324). There was no statistical difference in the adjusted means of the PHQ-9 score for those patients who were in remission at six months. However, in the unremitted patients, the six-month PHQ-9 score was significantly increased by initial depression severity when controlling for all other variables. Conclusion Multivariate analysis in our study demonstrated that patients with severe depression have a decreased OR for remission at six months compared with moderate depression. Also, there was a significant increase in the six-month PHQ-9 score for those unremitted patients in the severe vs. moderate depression groups.

Keywords: collaborative care management; depression; primary care.

Figures

Figure 1
Figure 1
Clinical response and remission after 6 months of treatment for depression in CCM of depression (intention to treat method).
Figure 2
Figure 2
Clinical response and remission after 6 months of treatment for depression in CCM of depression in re-measured patients
Figure 3
Figure 3
Adjusted means of 6-month PHQ-9 score, by depression severity for those patients in clinical remission and those not

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