Evaluation of antifungal activity of free fatty acids methyl esters fraction isolated from Algerian Linum usitatissimum L. seeds against toxigenic Aspergillus

Asian Pac J Trop Biomed. 2013 Jun;3(6):443-8. doi: 10.1016/S2221-1691(13)60094-5.

Abstract

Objective: The aim of this study was to evaluate the antifungal activity of the major fraction of fatty acids methyl esters (FAMEs) isolated from Linum usitatissimum L. seeds oil collected from Bechar department (Algeria).

Methods: The assessment of antifungal activity was carried out in terms of percentage of radial growth on solid medium (potatoes dextrose agar PDA) and biomass growth inhibition on liquid medium (potatoes dextrose broth PDB) against two fungi.

Results: The FAMEs was found to be effective in inhibiting the radial mycelial growth of Aspergillus flavus more than Aspergillus ochraceus on all tested concentrations. The highest antifungal index was found to be (54.19%) compared to Aspergillus ochraceus (40.48%). The results of the antifungal activity of the FAMEs inhibition of biomass on liquid medium gave no discounted results, but this does not exclude the antifungal activity.

Conclusions: We can assume that the observed antifungal potency may be due to the abundance of linoleic and α-linolenic acids in linseed oil which appears to be promising to treat fungal infections, storage fungi and food spoilage in food industry field.

Keywords: Antifungal activity; Aspergillus; Extraction; FAMEs; Linum usitatissimum L..

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algeria
  • Antifungal Agents / pharmacology*
  • Aspergillus flavus / drug effects*
  • Aspergillus ochraceus / drug effects*
  • Esters / pharmacology
  • Fatty Acids, Nonesterified / pharmacology
  • Flax / chemistry*
  • Fungicides, Industrial / pharmacology*
  • Linseed Oil / pharmacology*
  • Microbial Sensitivity Tests
  • Seeds / chemistry

Substances

  • Antifungal Agents
  • Esters
  • Fatty Acids, Nonesterified
  • Fungicides, Industrial
  • Linseed Oil