IL-17 targeted therapies for psoriasis

Expert Opin Investig Drugs. 2013 Aug;22(8):993-1005. doi: 10.1517/13543784.2013.806483. Epub 2013 Jun 3.


Introduction: Psoriasis is a chronic, disabling, inflammatory skin disease whose pathogenesis still remains to be fully elucidated. Genetic and environmental factors induce an immune response mediated by several cytokines and chemokines, including IL-17A.

Areas covered: Emerging evidence now suggests that IL-17A is central in the pathogenesis of psoriasis. Three agents neutralizing IL-17 (i.e., secukinumab and ixekizumab) or antagonizing its receptor (i.e., brodalumab) are in development and are being studied in Phase III clinical trials to evaluate their overall efficacy and safety. However, Phase II results of IL-17 blockade with each of these agents has shown a marked improvement of disease severity, thus confirming the pathogenic relevance of IL-17 in mediating crucial inflammatory circuits in psoriasis.

Expert opinion: Anti-IL-17 agents are likely to become important future therapeutics in this disease and the may potentially impact on cardiovascular diseases, arthritis and other comorbidities associated with psoriasis.

Publication types

  • Review

MeSH terms

  • Antibodies, Monoclonal / therapeutic use
  • Biological Factors / therapeutic use
  • Humans
  • Interleukin-17 / antagonists & inhibitors*
  • Interleukin-17 / immunology
  • Psoriasis / drug therapy*
  • Psoriasis / genetics
  • Psoriasis / immunology
  • Transcriptome


  • Antibodies, Monoclonal
  • Biological Factors
  • Interleukin-17