Muscle lipofuscin content and satellite cell volume is increased after high altitude exposure in humans

Experientia. 1990 Jul 15;46(7):672-6. doi: 10.1007/BF01939930.


Muscle ultrastructural changes during a typical expedition to the Himalayas were analyzed by taking muscle biopsies from seven climbers before and after their sojourn at high altitude (over 5000 m for 8 weeks). M. vastus lateralis samples were analyzed morphometrically from electron micrographs. A quantitative evaluation was made of lipofuscin, satellite cells and myonuclei. Significant increases of the volume densities of lipofuscin (+ 235%) and satellite cells (+ 215%) were observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Altitude*
  • Biopsy
  • Cell Nucleus / ultrastructure
  • Humans
  • Lipofuscin / metabolism*
  • Male
  • Muscles / cytology
  • Muscles / metabolism*
  • Muscles / ultrastructure
  • Pigments, Biological / metabolism*


  • Lipofuscin
  • Pigments, Biological