"TET-on" pluripotency

Cell Res. 2013 Jul;23(7):863-5. doi: 10.1038/cr.2013.72. Epub 2013 Jun 4.

Abstract

Recent studies have uncovered a specific role of TET proteins in reprogramming somatic cells to induced pluripotent stem cells, a process where O-linked β-N-acetylglucosamine transferase may play a crucial role.

MeSH terms

  • Animals
  • Cellular Reprogramming / genetics
  • Cellular Reprogramming / physiology*
  • DNA Methylation / genetics
  • DNA Methylation / physiology
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Dioxygenases / genetics
  • Dioxygenases / metabolism
  • Humans
  • Induced Pluripotent Stem Cells / cytology*
  • Induced Pluripotent Stem Cells / metabolism*
  • Mice
  • Mixed Function Oxygenases
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism

Substances

  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • TET1 protein, mouse
  • TET2 protein, human
  • Tet2 protein, mouse
  • Mixed Function Oxygenases
  • TET1 protein, human
  • TET3 protein, human
  • Dioxygenases
  • Tet3 protein, mouse