Association between caffeine intake and age at onset in Huntington's disease

Neurobiol Dis. 2013 Oct;58:179-82. doi: 10.1016/j.nbd.2013.05.013. Epub 2013 May 31.


Habitual consumption of caffeine, a non-selective adenosine receptor (AR) antagonist, has been suggested to be beneficial in Parkinson's and Alzheimer's diseases. Experimental evidence support that ARs play a role in Huntington's disease (HD) raising the hypothesis that caffeine may be a life-style modifier in HD. To determine a possible relationship between caffeine consumption and age at onset (AAO) in HD, we retrospectively assessed caffeine consumption in 80 HD patients using a dietary survey and determined relationship with AAO. Following adjustment for gender, smoking status and CAG repeat length, caffeine consumption greater than 190mg/day was significantly associated with an earlier AAO. These data support an association between habitual caffeine intake and AAO in HD patients, but further studies are warranted to understand the link between these variables.

Keywords: Adenosine receptors; Caffeine; Huntington's disease.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age of Onset
  • Caffeine / adverse effects*
  • Coffea / metabolism
  • Female
  • France
  • Humans
  • Huntington Disease / chemically induced*
  • Huntington Disease / epidemiology*
  • Huntington Disease / genetics
  • Linear Models
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Retrospective Studies
  • Self Report
  • Statistics, Nonparametric
  • Trinucleotide Repeat Expansion / genetics


  • Caffeine