Non-small cell lung cancer--genetic predictors

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013 Jun;157(2):125-36. doi: 10.5507/bp.2013.034. Epub 2013 May 29.


Background: Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer that is the leading cause of cancer-related mortality worldwide. Several predictive markers have been found in NSCLC patients to date but only a few are currently used for tailored therapy.

Methods and results: PubMed and Web of Science online databases were used to search review and original articles on the most important predictive markers in NSCLC.

Conclusion: EGFR activating mutations (exons 18 to 21) and EML4-ALK rearrangement are clinically important markers able to select NSCLC patients which benefit from EGFR or ALK tyrosine kinase inhibitors (gefitinib, erlotinib, crizotinib). Other markers, such as KRAS mutation, EGFR T790M mutation and C-MET amplification, are responsible for resistance to these inhibitors. Overcoming of this resistance as well as discovery of new potential markers and inhibitors is the main goal of ongoing research and clinical trials in NSCLC.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers, Tumor / genetics*
  • Carcinoma, Non-Small-Cell Lung / drug therapy
  • Carcinoma, Non-Small-Cell Lung / genetics*
  • Drug Resistance, Neoplasm
  • ErbB Receptors / drug effects
  • ErbB Receptors / genetics
  • Humans
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / genetics*
  • Oncogene Proteins, Fusion / drug effects
  • Oncogene Proteins, Fusion / genetics
  • Protein Kinase Inhibitors / pharmacology
  • Protein-Tyrosine Kinases / drug effects
  • Protein-Tyrosine Kinases / genetics
  • Proto-Oncogene Proteins / drug effects
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins c-met / drug effects
  • Proto-Oncogene Proteins c-met / genetics
  • Proto-Oncogene Proteins p21(ras)
  • ras Proteins / drug effects
  • ras Proteins / genetics


  • Biomarkers, Tumor
  • EML4-ALK fusion protein, human
  • KRAS protein, human
  • Oncogene Proteins, Fusion
  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins
  • ErbB Receptors
  • Protein-Tyrosine Kinases
  • Proto-Oncogene Proteins c-met
  • ROS1 protein, human
  • Proto-Oncogene Proteins p21(ras)
  • ras Proteins