Lung transplantation after lung volume reduction surgery

Transplantation. 2013 Aug 27;96(4):421-5. doi: 10.1097/TP.0b013e31829853ac.


Background: Lung volume reduction surgery (LVRS) as a bridge to lung transplantation was first advocated in 1995 and published studies have supported the concept but with limited data. The risk-benefit tradeoffs of the combined procedure have not been thoroughly examined, although substantial information regarding LVRS has emerged.

Methods: Of 177 patients who underwent lung transplantation for end-stage emphysema between 2002 and 2009 at our center, 25 had prior LVRS (22 bilateral and 3 unilateral). Lung transplantation was performed 22.9±15.9 months after LVRS. We compared in-hospital morbidity, functional capacity, and long-term outcomes of patients who underwent LVRS before lung transplantation with a matched cohort of patients without prior LVRS to assess the influence of LVRS on posttransplantation morbidity and mortality.

Results: The incidence of postoperative bleeding requiring reexploration and the incidence of renal dysfunction requiring dialysis were higher in patients with LVRS before lung transplantation. Posttransplantation peak forced expiratory volume in 1 s was worse in patients with LVRS before lung transplantation (56.7% vs. 78.8%; P<0.05). Five-year survival was not significantly different (59.7% in patients with LVRS before lung transplantation vs. 66.2% in patients with lung transplantation alone). In multivariate analysis, age more than 65 years, prolonged cardiopulmonary bypass time, and severe pulmonary hypertension were significant predictors for mortality (P<0.05).

Conclusions: Although LVRS remains a viable option as a bridge to lung transplantation in appropriately selected patients, LVRS before lung transplantation can impart substantial morbidity and compromised functional capacity after lung transplantation. LVRS should not be easily considered as a bridge to transplantation for all lung transplant candidates.

MeSH terms

  • Aged
  • Cohort Studies
  • Female
  • Humans
  • Hypertension, Pulmonary / etiology
  • Lung Transplantation / adverse effects*
  • Lung Transplantation / mortality
  • Lung Transplantation / physiology
  • Male
  • Middle Aged
  • Pneumonectomy* / adverse effects
  • Postoperative Complications / etiology
  • Prognosis
  • Pulmonary Disease, Chronic Obstructive / physiopathology
  • Pulmonary Disease, Chronic Obstructive / surgery
  • Pulmonary Emphysema / physiopathology
  • Pulmonary Emphysema / surgery
  • Retrospective Studies
  • Risk Factors
  • Treatment Outcome