Cysticlean® a highly pac standardized content in the prevention of recurrent urinary tract infections: an observational, prospective cohort study

BMC Urol. 2013 Jun 5:13:28. doi: 10.1186/1471-2490-13-28.


Background: The present study was aimed at determining the prophylactic efficacy of American cranberry (AC) extract (Cysticlean®) in women with recurrent symptomatic postcoital urinary tract infections (PCUTI), non-consumer of AC extract in the past 3 months before inclusion, and to determine changes in their quality of life (QoL).

Methods: This was a single center, observational, prospective study in a total of 20 women (mean age 35.2 years; 50.0% were married). Patients were followed up for 3 and 6 months during treatment.

Results: The number of PCUTIs in the previous 3 months prior to start the treatment with Cysticlean® was 2.8±1.3 and it was reduced to 0.2±0.5 at Month 6 (P<0.0001), which represent a 93% improvement. At baseline, the mean score on the VAS scale (range from 0 to 100) for assessing the QoL was 62.4±19.1, increasing to 78.2±12.4 at Month 6 (P=0.0002), which represents a 20% improvement. All patients had an infection with positive urine culture at baseline, after 6 months there were only 3 symptomatic infections (P<0.001). The most common bacterium was Escherichia coli.

Conclusions: Prophylaxis with American cranberry extract (Cysticlean®) could be an alternative to classical therapies with antibiotics. Further studies are needed to confirm results obtained in this pilot study.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anti-Bacterial Agents / standards
  • Anti-Bacterial Agents / therapeutic use
  • Bacterial Infections / drug therapy*
  • Bacterial Infections / prevention & control*
  • Bacterial Infections / psychology
  • Cohort Studies
  • Coitus
  • Dietary Supplements / standards
  • Female
  • Humans
  • Middle Aged
  • Proanthocyanidins / standards
  • Proanthocyanidins / therapeutic use*
  • Prospective Studies
  • Quality of Life / psychology*
  • Secondary Prevention
  • Spain
  • Treatment Outcome
  • United States
  • Urinary Tract Infections / drug therapy*
  • Urinary Tract Infections / prevention & control*
  • Urinary Tract Infections / psychology
  • Young Adult


  • Anti-Bacterial Agents
  • Cysticlean
  • Proanthocyanidins