Perna canaliculus lipid complex PCSO-524™ demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control

Mar Drugs. 2013 Jun 5;11(6):1920-35. doi: 10.3390/md11061920.


Osteoarthritis (OA) typically generates pain, reduced mobility and reduced quality of life. Most conventional treatments for osteoarthritis, such as non-steroidal anti-inflammatory drugs (NSAIDs) and simple analgesics, have side effects. PCSO-524™, a non polar lipid extract from the New Zealand Green Lipped Mussel, is rich in omega-3 fatty acids and has been shown to reduce inflammation in both animal studies and patient trials. This OA trial examined pain relief changes in relation to quality of life and safety of use for OA patients who took PCSO-524™ compared with patients who took fish oil (containing an industry standard EPA-18% and DHA-12% blend). PCSO-524™ patients showed a statistically significant improvement compared with patients who took fish oil. There was an 89% decrease in their pain symptoms and 91% reported an improved quality of life. Patients treated with fish oil showed significantly less improvement and a greater level of physical discomfort during the study. These results suggest that PCSO-524™ might offer a potential alternative complementary therapy with no side effects for OA patients.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Animals
  • Complementary Therapies / methods
  • Docosahexaenoic Acids / adverse effects
  • Docosahexaenoic Acids / therapeutic use
  • Double-Blind Method
  • Eicosapentaenoic Acid / adverse effects
  • Eicosapentaenoic Acid / therapeutic use
  • Fatty Acids, Omega-3 / adverse effects
  • Fatty Acids, Omega-3 / isolation & purification
  • Fatty Acids, Omega-3 / therapeutic use
  • Female
  • Fish Oils / adverse effects
  • Fish Oils / therapeutic use
  • Humans
  • Lipids / adverse effects
  • Lipids / isolation & purification
  • Lipids / therapeutic use*
  • Male
  • Middle Aged
  • Osteoarthritis / complications*
  • Pain / drug therapy*
  • Pain / etiology
  • Perna / chemistry*
  • Quality of Life
  • Treatment Outcome


  • Fatty Acids, Omega-3
  • Fish Oils
  • Lipids
  • Docosahexaenoic Acids
  • Eicosapentaenoic Acid