Triplex-Inspector: an analysis tool for triplex-mediated targeting of genomic loci

Bioinformatics. 2013 Aug 1;29(15):1895-7. doi: 10.1093/bioinformatics/btt315. Epub 2013 Jun 5.

Abstract

Summary: At the heart of many modern biotechnological and therapeutic applications lies the need to target specific genomic loci with pinpoint accuracy. Although landmark experiments demonstrate technological maturity in manufacturing and delivering genetic material, the genomic sequence analysis to find suitable targets lags behind. We provide a computational aid for the sophisticated design of sequence-specific ligands and selection of appropriate targets, taking gene location and genomic architecture into account.

Availability: Source code and binaries are downloadable from www.bioinformatics.org.au/triplexator/inspector.

Contact: t.bailey@uq.edu.au

Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / chemistry*
  • Gene Targeting*
  • Genetic Loci
  • Genomics
  • Humans
  • Peptide Nucleic Acids / chemistry
  • Software*

Substances

  • Peptide Nucleic Acids
  • triplex DNA
  • DNA