Recurrence after liver transplantation for hepatocellular carcinoma according to up-to-seven criteria

Hepatogastroenterology. 2013 Jun;60(124):799-806. doi: 10.5754/hge12997. Epub 2013 Jun 6.


Background/aims: The Up7 criteria for HCC have recently emerged to identify potential candidates for OLT. The aim of this study was to assess the validity of the Up7 criteria according to the pathological analysis of the explanted livers.

Methodology: For recurrence risk calculation 669 HCC transplanted patients were classified according to both the pathological Milan and Up7 criteria. In order to identify potential predictors of recurrence, selected biological tumor markers and morphological features were then tested by Cox regression.

Results: The 5-year HCC recurrence rate for the Milan out/Up7 in subgroup (n=87), was significantly higher than patients meeting Milan criteria (n=299), 15.8% vs. 9.4% (p=0.0290). For patients within the Up7 criteria (n=383), only pre-OLT AFP level >1000ng/mL and microvascular invasion were significant predictors for recurrence, and for those beyond the Up7 criteria (n=286), pre-OLT AFP level >1000ng/mL, poor differentiation grade and microvascular invasion remained significant.

Conclusions: Compared to the current Milan staging system, HCC patients within the pathological Up7 criteria were associated with a higher, but acceptable risk of recurrence after OLT, and along with tumor burden, other parameters can potentially be used for further refinement of HCC staging, such as AFP levels and microvascular invasion.

Publication types

  • Multicenter Study

MeSH terms

  • Carcinoma, Hepatocellular / pathology*
  • Female
  • France
  • Humans
  • Liver Neoplasms / pathology*
  • Liver Transplantation*
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / pathology*
  • Patient Selection*
  • Retrospective Studies
  • Risk Assessment
  • Survival Rate