Monocyte and Macrophage Heterogeneity in the Heart

Circ Res. 2013 Jun 7;112(12):1624-33. doi: 10.1161/CIRCRESAHA.113.300890.


Monocytes and macrophages are innate immune cells that reside and accumulate in the healthy and injured heart. The cells and their subsets pursue distinct functions in steady-state and disease, and their tenure may range between hours and months. Some subsets are highly inflammatory, whereas others support tissue repair. This review discusses current concepts of lineage relationships and crosstalk of systems, highlights open questions, and describes tools for studying monocyte and macrophage subsets in the murine and human heart.

Keywords: healing; heart failure; macrophages; monocytes; myocardial infarction.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Biomarkers / metabolism
  • Cell Lineage
  • Heart Failure / immunology*
  • Heart Failure / pathology
  • Humans
  • Macrophages / immunology*
  • Monocytes / immunology*
  • Myocardial Infarction / immunology*
  • Myocardial Infarction / pathology
  • Myocardium / immunology*
  • Myocardium / pathology
  • Regeneration
  • Signal Transduction
  • Wound Healing


  • Biomarkers