Incidence of appropriate shock in implantable cardioverter-defibrillator patients with improved ejection fraction

J Card Fail. 2013 Jun;19(6):426-30. doi: 10.1016/j.cardfail.2013.04.007.


Background: Heart failure with recovered ejection fraction (EF) is a recently described clinical entity. There is insufficient information on the management of implantable-cardioverter defibrillator (ICD) patients with improved EF at generator replacement.

Methods and results: We examined the incidence of appropriate shocks in 91 consecutive patients with ICDs for primary prevention of sudden death who underwent generator replacement. Improved EF was defined as both EF >35% at generator replacement and increase in EF by ≥10% since original implantation. Patients were 70 ± 11 years old, and 76% had ischemic cardiomyopathy. At generator replacement, 25 patients (27%) had improved EF (0.49 ± 0.08 vs 0.31 ± 0.07 at baseline; P < .0001). Over 6.2 ± 2.2 years of follow-up after original implantation, 9 patients (36%) with improved EF versus 19 (29%) with unchanged EF had appropriate ICD shocks (P = .51). Incidence of appropriate ICD shocks was similar between the two groups before (P = .90) and after (P = .97) generator replacement. Of the 9 improved EF patients with appropriate shock, 4 had shocks before generator replacement, 2 had shocks before and after generator replacement, and 3 patients, who never had shocks before, had their first shock after generator replacement.

Conclusions: Some ICD patients whose EF improves to >35% at generator replacement remain at risk for appropriate ICD shocks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cardiomyopathies / therapy
  • Death, Sudden, Cardiac / prevention & control
  • Defibrillators, Implantable*
  • Female
  • Follow-Up Studies
  • Heart Failure / therapy*
  • Humans
  • Logistic Models
  • Male
  • Myocardial Ischemia / therapy
  • Primary Prevention
  • Stroke Volume / physiology*
  • Tachycardia / prevention & control