Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults

J Hypertens. 2013 Sep;31(9):1819-27. doi: 10.1097/HJH.0b013e328362b9d6.


Background: We have previously demonstrated acute dose-dependent increases of flow-mediated dilatation (FMD) in the brachial artery after resveratrol consumption in mildly hypertensive, overweight/obese adults. Resveratrol supplementation has also been shown to increase cerebral blood flow acutely, without affecting cognition.

Objectives: To evaluate the effects of chronic resveratrol supplementation on both FMD and cognitive performance.

Method: Twenty-eight obese but otherwise healthy adults (BMI: 33.3 ± 0.6 kg/m) were randomized to take a single 75 mg capsule of trans-resveratrol (Resvida) or placebo daily for 6 weeks each in a double-blind crossover supplementation trial. Blood pressure, arterial compliance, FMD, and performance on the Stroop Color-Word Test were assessed at the end of each 6-week intervention period while fasted and at least 18 h after taking the last daily capsule. An additional capsule of the same supplement was then taken. FMD assessment was repeated 1 h later.

Results: Chronic resveratrol supplementation for 6 weeks was well tolerated and resulted in a 23% increase in FMD compared with placebo (P=0.021, paired t-test). The extent of increase correlated negatively with baseline FMD (r=-0.47, P=0.01). A single dose of resveratrol (75 mg) following chronic resveratrol supplementation resulted in a 35% greater acute FMD response than the equivalent placebo supplementation. These FMD improvements remained significant after adjusting for baseline FMD. Blood pressure, arterial compliance, and all components of the Stroop Color-Word Test were unaffected by chronic resveratrol supplementation.

Conclusion: Daily resveratrol consumption was well tolerated and has the potential to maintain healthy circulatory function in obese adults.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Blood Flow Velocity / drug effects
  • Blood Pressure
  • Blood Pressure Monitoring, Ambulatory
  • Body Mass Index
  • Brachial Artery / drug effects*
  • Brachial Artery / pathology
  • Carotid Arteries / pathology
  • Cross-Over Studies
  • Dietary Supplements
  • Double-Blind Method
  • Endothelium, Vascular / physiopathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Obesity / physiopathology*
  • Overweight
  • Postmenopause
  • Resveratrol
  • Stilbenes / therapeutic use*
  • Stroop Test
  • Surveys and Questionnaires
  • Vasodilation / drug effects*


  • Stilbenes
  • Resveratrol