Does a monovalent inactivated human rotavirus vaccine induce heterotypic immunity? Evidence from animal studies

Hum Vaccin Immunother. 2013 Aug;9(8):1634-7. doi: 10.4161/hv.24958. Epub 2013 Jun 6.

Abstract

There is substantial evidence for broad cross-reactive immunity and heterotypic protection among human rotavirus strains in children with natural infection or with monovalent Rotarix vaccination. In this commentary, we addressed this same topic by testing sera of guinea pigs and gnotobiotic piglets that were intramuscularly immunized with an inactivated human rotavirus vaccine and also demonstrated a broad cross-protective immunity among human rotavirus strains. Our findings from a single human strain in animal studies bode well for a low cost and efficacious inactivated vaccine to protect children against rotavirus disease throughout the world.

Keywords: CDC-9; IRV; heat inactivation; heterotypic protection; rotavirus.

MeSH terms

  • Animals
  • Antibodies, Neutralizing / blood
  • Antibodies, Neutralizing / immunology
  • Antibodies, Viral / blood
  • Antibodies, Viral / immunology*
  • Child
  • Child, Preschool
  • Cross Protection*
  • Cross Reactions
  • Guinea Pigs
  • Humans
  • Injections, Intramuscular
  • Rotavirus Infections / prevention & control*
  • Rotavirus Vaccines / administration & dosage
  • Rotavirus Vaccines / immunology*
  • Swine
  • Vaccines, Attenuated / administration & dosage
  • Vaccines, Attenuated / immunology
  • Vaccines, Inactivated / administration & dosage
  • Vaccines, Inactivated / immunology

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral
  • RIX4414 vaccine
  • Rotavirus Vaccines
  • Vaccines, Attenuated
  • Vaccines, Inactivated