Tm(DOTP)5-: a 23Na+ shift agent for perfused rat hearts

Magn Reson Med. 1990 Jul;15(1):25-32. doi: 10.1002/mrm.1910150104.


Tm(DOTP)5-, the thulium(III) complex of 1,4,7,10-tetraazacyclododecane-N,N',N',N'''-tetra(methylenephos p hon ate), is introduced as a 23Na+ shift agent for use in discrimination of the NMR resonances of intra- and extracellular 23Na+ ions in perfused rat hearts. The novel shift agent is directly compared to the widely used Dy(TTHA)3- (dysprosium(III) triethylenetetraminehexaacetate).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Heart
  • Indicators and Reagents
  • Magnetic Resonance Spectroscopy*
  • Myocardium / analysis*
  • Oxazoles*
  • Perfusion
  • Pyrimidinones*
  • Rats
  • Sodium / analysis*
  • Thulium*


  • Indicators and Reagents
  • Oxazoles
  • Pyrimidinones
  • 2,3-dihydro-5H-oxazolo(3,2-a)thieno(3,2-d)pyrimidin-5-one
  • Thulium
  • Sodium