Movement of internalized ligand-receptor complexes along a continuous endosomal reticulum

Nature. 1990 Jul 26;346(6282):335-9. doi: 10.1038/346335a0.


Complexes of cell-surface receptors and their ligands are commonly internalized by endocytosis and enter a prelysosomal endosomal pathway for further processing. Fluorescence microscopy and video recording of living cells to trace the passage of ligand-receptor complexes has identified the endosomal compartment as an extensive network of tubular cisternae. Endocytosed material entering this reticulum enters discrete swellings, identified as multivesicular bodies by electron microscopy, which move along the reticulum towards the pericentriolar area.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Transport
  • Cell Line
  • Cell Membrane / metabolism
  • Cell Membrane / ultrastructure
  • Endocytosis*
  • ErbB Receptors / metabolism*
  • ErbB Receptors / ultrastructure
  • Humans
  • Microscopy, Electron
  • Microscopy, Fluorescence
  • Receptors, Transferrin / metabolism*
  • Receptors, Transferrin / ultrastructure


  • Receptors, Transferrin
  • ErbB Receptors