Distinct resident and recirculating memory T cell subsets in non-lymphoid tissues

Curr Opin Immunol. 2013 Jun;25(3):329-33. doi: 10.1016/j.coi.2013.05.007. Epub 2013 Jun 5.


Antigen experienced or memory T cells make a critical contribution to immunity against infection. Many pathogens colonise non-lymphoid tissues and memory T cells in these compartments can deal with such localised infections. Emerging data show that there are at least two phenotypically distinct peripheral T cell subsets, one permanently resident and one recirculating between tissues and blood. A full appreciation of the T cells in the non-lymphoid memory pool and their relationship to those in the circulation is an important step in understanding how to generate and exploit effective peripheral immunity for the purpose of infection control.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement*
  • Humans
  • Immunologic Memory*
  • Lymphoid Tissue / immunology
  • Phenotype
  • T-Lymphocyte Subsets / cytology
  • T-Lymphocyte Subsets / immunology*