Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6

Oncogene. 1990 Jul;5(7):1095-7.

Abstract

We report here the full length cDNA sequence and the deduced amino-acid sequence of MyD88, a novel myeloid differentiation primary response gene activated in M1D+ myeloid precursors, following induction of terminal differentiation and growth arrest by IL6. Detectable levels of MyD88 RNA were observed in myeloid precursor enriched murine bone-marrow, but not in several other non-myeloid murine tissues.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Amino Acid Sequence
  • Animals
  • Antigens, Differentiation*
  • Base Sequence
  • Bone Marrow / physiology*
  • Bone Marrow Cells
  • Cell Differentiation* / drug effects
  • Cells, Cultured
  • Cloning, Molecular
  • DNA / genetics
  • Gene Expression
  • Interleukin-6 / pharmacology*
  • Mice
  • Molecular Sequence Data
  • Myeloid Differentiation Factor 88
  • Proteins / genetics*
  • Receptors, Immunologic*
  • Time Factors

Substances

  • Adaptor Proteins, Signal Transducing
  • Antigens, Differentiation
  • Interleukin-6
  • Myd88 protein, mouse
  • Myeloid Differentiation Factor 88
  • Proteins
  • Receptors, Immunologic
  • DNA

Associated data

  • GENBANK/X51397