Double-blind placebo-controlled trial of hydroxytyrosol of Olea europaea on pain in gonarthrosis

Phytomedicine. 2013 Jul 15;20(10):861-4. doi: 10.1016/j.phymed.2013.03.021. Epub 2013 Jun 7.


Hydroxytyrosol is mainly found in olive leaves after hydrolysis of oleuropein and has anti-oxidant, anti-bacterial, and anti-inflammatory properties. The aim of this study was to investigate the effect of hydroxytyrosol for alleviating the pain in patients with gonarthrosis. We conducted a double-blind clinical trial in which hydroxytyrosol or placebo was administered to adult patients with gonarthrosis for 4 weeks. The group administered hydroxytyrosol showed significant improvement in the Japanese Orthopedic Association score (pain measurement index) and the visual analog scale score compared to the placebo group.

Keywords: Gonarthrosis; Hydroxytyrosol; Olea europaea; Olive; Pain.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Aged
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Olea*
  • Osteoarthritis, Knee / drug therapy*
  • Pain Measurement
  • Phenylethyl Alcohol / analogs & derivatives*
  • Phenylethyl Alcohol / therapeutic use
  • Phytotherapy
  • Plant Extracts / chemistry
  • Plant Extracts / therapeutic use*


  • Plant Extracts
  • 3,4-dihydroxyphenylethanol
  • Phenylethyl Alcohol