A radical signal activates the epigenetic regulation of longevity

Mario G Mirisola; Valter D Longo

doi:10.1016/j.cmet.2013.05.015

A radical signal activates the epigenetic regulation of longevity

Cell Metab. 2013 Jun 4;17(6):812-813. doi: 10.1016/j.cmet.2013.05.015.

Authors

Mario G Mirisola¹, Valter D Longo²

Affiliations

¹ Department of Medical and Forensic Biotechnology (DiBiMeF), University of Palermo, via Divisi 83, 90133 Palermo, Italy; Longevity Institute, School of Gerontology and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA.
² Longevity Institute, School of Gerontology and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA. Electronic address: vlongo@usc.edu.

PMID: 23747240
DOI: 10.1016/j.cmet.2013.05.015

Abstract

Hormesis is an adaptive stress response implicated in longevity regulation. Schroeder et al. (2013) have now connected stress, epigenetic changes, and aging in yeast by showing that mitochondria-derived reactive oxygen species modulate the chromatin binding capacity of the histone demethylase Rph1p at subtelomeres, resulting in lifespan extension.

Publication types

Comment

MeSH terms

Cell Cycle Proteins / metabolism*
Checkpoint Kinase 2 / metabolism*
DNA Repair / genetics*
Intracellular Signaling Peptides and Proteins / metabolism*
Longevity / genetics*
Mitochondria / metabolism*
Protein Serine-Threonine Kinases / metabolism*
Saccharomyces cerevisiae Proteins / metabolism*

Substances

Cell Cycle Proteins
Intracellular Signaling Peptides and Proteins
Saccharomyces cerevisiae Proteins
Checkpoint Kinase 2
Protein Serine-Threonine Kinases
TEL1 protein, S cerevisiae
RAD53 protein, S cerevisiae