A radical signal activates the epigenetic regulation of longevity

Cell Metab. 2013 Jun 4;17(6):812-813. doi: 10.1016/j.cmet.2013.05.015.


Hormesis is an adaptive stress response implicated in longevity regulation. Schroeder et al. (2013) have now connected stress, epigenetic changes, and aging in yeast by showing that mitochondria-derived reactive oxygen species modulate the chromatin binding capacity of the histone demethylase Rph1p at subtelomeres, resulting in lifespan extension.

Publication types

  • Comment

MeSH terms

  • Cell Cycle Proteins / metabolism*
  • Checkpoint Kinase 2 / metabolism*
  • DNA Repair / genetics*
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Longevity / genetics*
  • Mitochondria / metabolism*
  • Protein Serine-Threonine Kinases / metabolism*
  • Saccharomyces cerevisiae Proteins / metabolism*


  • Cell Cycle Proteins
  • Intracellular Signaling Peptides and Proteins
  • Saccharomyces cerevisiae Proteins
  • Checkpoint Kinase 2
  • Protein Serine-Threonine Kinases
  • TEL1 protein, S cerevisiae
  • RAD53 protein, S cerevisiae