Immunological goings-on in visceral adipose tissue

Cell Metab. 2013 Jun 4;17(6):851-859. doi: 10.1016/j.cmet.2013.05.008.


Chronic, low-grade inflammation of visceral adipose tissue, and systemically, is a critical link between recent strikingly parallel rises in the incidence of obesity and type 2 diabetes. Macrophages have been recognized for some time to be critical participants in obesity-induced inflammation of adipose tissue. Of late, a score of other cell types of the innate and adaptive arms of the immune system have been suggested to play a positive or negative role in adipose tissue infiltrates. This piece reviews the existing data on these new participants; discusses experimental uncertainties, inconsistencies, and complexities; and puts forward a minimalist synthetic scheme.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • B-Lymphocytes / immunology
  • Diabetes Mellitus, Type 2 / metabolism*
  • Humans
  • Inflammation / immunology
  • Insulin Resistance / immunology*
  • Intra-Abdominal Fat / immunology*
  • Intra-Abdominal Fat / metabolism
  • Macrophages / immunology
  • Macrophages / metabolism
  • Natural Killer T-Cells / immunology
  • Obesity / metabolism*
  • T-Lymphocytes / immunology