Innate immune receptors: key regulators of metabolic disease progression

Cell Metab. 2013 Jun 4;17(6):873-882. doi: 10.1016/j.cmet.2013.05.011.


The study of the intersection of immunology and metabolism is a growing field fueled by the increased prevalence of obesity-associated pathologies. Importantly, the capacity of the innate immune system to sense metabolic stress induced by nutritional surplus has been linked with the progression of obesity, insulin resistance, type 2 diabetes mellitus, nonalcoholic fatty liver disease, and atherosclerosis. Moreover, it is clear that the innate immune system regulates the composition of the intestinal microbiota, which impacts multiple host metabolic processes. Here we review recent studies in this emerging field with an emphasis on how innate immune receptors determine metabolic disease progression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Atherosclerosis / immunology
  • Atherosclerosis / metabolism
  • Diabetes Mellitus, Type 2 / immunology
  • Diabetes Mellitus, Type 2 / metabolism
  • Disease Progression
  • Fatty Liver / immunology
  • Fatty Liver / metabolism
  • Humans
  • Immunity, Innate*
  • Inflammation / immunology
  • Insulin Resistance / immunology
  • Intestines / immunology
  • Intestines / microbiology
  • Metabolic Diseases / immunology*
  • Non-alcoholic Fatty Liver Disease
  • Obesity / immunology*
  • Obesity / metabolism
  • Receptors, Immunologic / immunology*


  • Receptors, Immunologic