Magnetic separations in biotechnology

Biotechnol Adv. 2013 Dec;31(8):1374-85. doi: 10.1016/j.biotechadv.2013.05.009. Epub 2013 Jun 6.

Abstract

Magnetic separations are probably one of the most versatile separation processes in biotechnology as they are able to purify cells, viruses, proteins and nucleic acids directly from crude samples. The fast and gentle process in combination with its easy scale-up and automation provide unique advantages over other separation techniques. In the midst of this process are the magnetic adsorbents tailored for the envisioned target and whose complex synthesis spans over multiple fields of science. In this context, this article reviews both the synthesis and tailoring of magnetic adsorbents for bioseparations as well as their ultimate application.

Keywords: Automation; Magnetic particles; Magnetic separations; Purification; Synthesis.

Publication types

  • Review

MeSH terms

  • Biotechnology*
  • Magnetic Fields*
  • Magnetite Nanoparticles*
  • Nucleic Acids / isolation & purification
  • Proteins / isolation & purification

Substances

  • Magnetite Nanoparticles
  • Nucleic Acids
  • Proteins