A trivial role of STAT4 variant in chronic hepatitis B induced hepatocellular carcinoma

Infect Genet Evol. 2013 Aug;18:257-61. doi: 10.1016/j.meegid.2013.05.025. Epub 2013 Jun 6.

Abstract

Two polymorphisms in the STAT4 and HLA-DQ loci were more recently reported to associate with chronic hepatitis B (CHB) induced hepatocellular carcinoma (HCC). We utilised an independent Vietnamese cohort of clinically classified HBV patients of chronic hepatitis B carriers (n=206), liver cirrhosis (n=222) and hepatocellular carcinoma (n=239) and assessed the influence of the reported variants. The STAT4 variant (rs7574865) was marginally associated with HCC susceptibility in CHB carriers in allelic and recessive genetic models (OR=0.84, 95%CI=0.7-0.99, P=0.048 and OR=0.7, 95%CI=0.5-0.99, P=0.047). No significant association between the studied variant with several clinical parameters such as liver enzymes (ALT, AST), total and direct bilirubin, AFP, HBV genotype and viral loads were observed. Our study highlights the reported variant to be a trivial factor and possibly other confounding factors may regulate STAT4 expression during HCC development.

Keywords: CHB induced HCC; HBV infection; HLA-DQ locus; STAT4.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Carcinoma, Hepatocellular / genetics
  • Carcinoma, Hepatocellular / virology*
  • Case-Control Studies
  • Disease Progression
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Hepatitis B, Chronic / complications*
  • Hepatitis B, Chronic / genetics
  • Humans
  • Liver Neoplasms / genetics
  • Liver Neoplasms / virology*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • STAT4 Transcription Factor / genetics*
  • Young Adult

Substances

  • STAT4 Transcription Factor
  • STAT4 protein, human