Inhibition of amyloid β aggregation by acteoside, a phenylethanoid glycoside

Biosci Biotechnol Biochem. 2013;77(6):1329-32. doi: 10.1271/bbb.130101. Epub 2013 Jun 7.

Abstract

We examined the effects of acteoside (1a), which was isolated from Orobanche minor, and its derivatives on the aggregation of a 42-mer amyloid β protein (Aβ42) in our search for anti-amyloidogenic compounds for Alzheimer's disease (AD) therapy. Acteoside (1a) strongly inhibited the aggregation of Aβ42 in a dose-dependent manner. The structure-activity relationship for acteoside (1a) and related compounds suggests the catechol moiety of phenylethanoid glycosides to be essential for this inhibitory activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Amyloid beta-Peptides / drug effects
  • Amyloid beta-Peptides / metabolism*
  • Catechols / metabolism
  • Dose-Response Relationship, Drug
  • Glucosides / administration & dosage*
  • Glucosides / chemistry
  • Humans
  • Orobanche / chemistry
  • Peptide Fragments / chemistry
  • Phenols / administration & dosage*
  • Phenols / chemistry
  • Plant Extracts / administration & dosage*
  • Plant Extracts / chemistry
  • Structure-Activity Relationship

Substances

  • Amyloid beta-Peptides
  • Catechols
  • Glucosides
  • Peptide Fragments
  • Phenols
  • Plant Extracts
  • acteoside
  • catechol