Abstract
We examined the effects of acteoside (1a), which was isolated from Orobanche minor, and its derivatives on the aggregation of a 42-mer amyloid β protein (Aβ42) in our search for anti-amyloidogenic compounds for Alzheimer's disease (AD) therapy. Acteoside (1a) strongly inhibited the aggregation of Aβ42 in a dose-dependent manner. The structure-activity relationship for acteoside (1a) and related compounds suggests the catechol moiety of phenylethanoid glycosides to be essential for this inhibitory activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alzheimer Disease / drug therapy*
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Amyloid beta-Peptides / drug effects
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Amyloid beta-Peptides / metabolism*
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Catechols / metabolism
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Dose-Response Relationship, Drug
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Glucosides / administration & dosage*
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Glucosides / chemistry
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Humans
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Orobanche / chemistry
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Peptide Fragments / chemistry
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Phenols / administration & dosage*
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Phenols / chemistry
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Plant Extracts / administration & dosage*
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Plant Extracts / chemistry
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Structure-Activity Relationship
Substances
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Amyloid beta-Peptides
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Catechols
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Glucosides
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Peptide Fragments
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Phenols
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Plant Extracts
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acteoside
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catechol