The influence of taurine pretreatment on aluminum chloride induced nephrotoxicity in Swiss albino mice

Histol Histopathol. 2014 Jan;29(1):45-55. doi: 10.14670/HH-29.45. Epub 2013 Jun 10.

Abstract

The present study was carried out to investigate (1) the alterations in biochemical parameters, free radicals and enzyme activities induced by aluminum chloride (AlCl₃) in kidney of male Swiss albino mice, and (2) the role of taurine in alleviating the nephrotoxic effects of AlCl₃. Taurine plays an important role as an antioxidant and is consequently expected to protect tissues from damage caused by reactive oxygen metabolites.The animals were randomized into four groups (n=6/group). Group I was the control group. Group II received a single dose of AlCl₃ (25 mg Al³⁺/kg b.w, ip). Group III received taurine (100 mg/kg b.w., ip) for 5 consecutive days before administration of AlCl₃ (25 mg Al³⁺/kg b.w, ip). Group IV received taurine (100 mg/kg b.w., ip) for 5 consecutive days. 24 h following the administration of compounds, all the mice were assessed using serum and tissue homogenate biomarkers as well as the pathological evaluation. Exposure to AlCl₃ led to an increased level of renal lipid peroxidation as measured by malondialdehyde (MDA), while reduced glutathione (GSH), glutathione peroxidase (GPx) and catalase (CAT) decreased. Marked elevation of blood urea and serum creatinine concentrations were also observed in AlCl₃ treated mice, thereby indicating renal damage. All these factors were significantly improved by taurine pretreatment. The histological and ultrastructural observations on the kidney tissues also confirmed the renoprotective nature of taurine. Thus these results may indicate that taurine treatment protects against functional, biochemical and morphological damage in AlCl₃-induced acute renal failure in mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Kidney Injury / chemically induced
  • Acute Kidney Injury / pathology
  • Acute Kidney Injury / prevention & control*
  • Aluminum Chloride
  • Aluminum Compounds / toxicity*
  • Animals
  • Antioxidants / pharmacology*
  • Chlorides / toxicity*
  • Kidney / drug effects
  • Kidney Function Tests
  • Male
  • Mice
  • Microscopy, Electron, Transmission
  • Taurine / pharmacology*

Substances

  • Aluminum Compounds
  • Antioxidants
  • Chlorides
  • Taurine
  • Aluminum Chloride