An isolated penile mass in a young adult turned out to be a primary marginal zone lymphoma of the penis. A case report and a review of literature

Anticancer Res. 2013 Jun;33(6):2639-42.


Aim: to discuss the rationale of the management of penile MALT lymphoma.

Case report: A 24-year-old patient presented with a painless and mobile nodule localized in the ventral part of the penis. The lesion was firstly evaluated through Doppler ultrasonography, which showed a hypoechoic and vascularized solid mass, a subsequent magnetic resonance confirmed size and position of the lesion. Subsequently the patient underwent a surgical excision of the mass, the pathological diagnosis was consistent with penile lymphoma, MALT-type. The patient underwent a consolidative immunotherapy with rituximab. Disease re-staging was performed through a MR without any detection of local or systemic recurrences.

Conclusion: To our knowledge, no cases of MALT lymphoma involving the penis have been reported in the literature so far. Surgical excision with organ sparing and immunotherapy with rituximab, successfully induced a complete response. Based upon this experience, we may recommend a conservative surgery associated with a systemic approach.

Keywords: MALT lymphoma; penile tumor.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antibodies, Monoclonal, Murine-Derived / therapeutic use
  • Antineoplastic Agents / therapeutic use
  • Humans
  • Lymphoma, B-Cell, Marginal Zone* / diagnosis
  • Lymphoma, B-Cell, Marginal Zone* / diagnostic imaging
  • Lymphoma, B-Cell, Marginal Zone* / drug therapy
  • Lymphoma, B-Cell, Marginal Zone* / surgery
  • Male
  • Organ Sparing Treatments
  • Penile Neoplasms* / diagnosis
  • Penile Neoplasms* / diagnostic imaging
  • Penile Neoplasms* / drug therapy
  • Penile Neoplasms* / surgery
  • Penis / pathology
  • Penis / surgery
  • Radiography
  • Rituximab
  • Young Adult


  • Antibodies, Monoclonal, Murine-Derived
  • Antineoplastic Agents
  • Rituximab