New fluorescent probes for sulfane sulfurs and the application in bioimaging

Chem Sci. 2013 May 9;4(7):2892-2896. doi: 10.1039/C3SC50754H.


A sulfane sulfur mediated benzodithiolone formation was developed. Based on this reaction, two fluorescent probes (SSP1 and SSP2) for the detection of sulfane sulfur species (persulfide, polysulfide, and elemental sulfur) were prepared and evaluated. The probes showed high selectivity and sensitivity to sulfane sulfurs. Moreover, SSP2 was successfully applied for bioimaging sulfane sulfurs in living cells.