Dynamic Guiding of Motor-Driven Microtubules on Electrically Heated, Smart Polymer Tracks

Nano Lett. 2013 Jul 10;13(7):3434-8. doi: 10.1021/nl402004s. Epub 2013 Jun 10.

Abstract

Biomolecular motor systems are attractive for future nanotechnological devices because they can replace nanofluidics by directed transport. However, the lack of methods to externally control motor-driven transport along complex paths limits their range of applications. Based on a thermo-responsive polymer, we developed a novel technique to guide microtubules propelled by kinesin-1 motors on a planar surface. Using electrically heated gold microstructures, the polymers were locally collapsed, creating dynamically switchable tracks that successfully guided microtubule movement.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Energy Transfer
  • Heating / methods
  • Kinesin / chemistry*
  • Kinesin / ultrastructure*
  • Microtubules / chemistry*
  • Microtubules / ultrastructure*
  • Molecular Motor Proteins / chemistry*
  • Molecular Motor Proteins / ultrastructure*
  • Motion
  • Transducers*

Substances

  • KIF5B protein, human
  • Molecular Motor Proteins
  • Kinesin