From NAFLD in clinical practice to answers from guidelines

J Hepatol. 2013 Oct;59(4):859-71. doi: 10.1016/j.jhep.2013.05.044. Epub 2013 Jun 7.


This review of the literature consists of three sections. First, papers concerning non-alcoholic fatty liver disease (NAFLD) awareness among the general population, general practitioners, and liver and non-liver specialists were retrieved and analyzed to highlight the perception of disease, verify knowledge of current recommendations, and identify the main difficulties experienced in clinical practice. Next, position papers and clinical practice guidelines issued by International and National Hepatological Scientific Societies were identified and critically assessed in order to pinpoint the areas of convergence/difference. Finally, practical suggestions on NAFLD diagnosis and management in daily practice are provided and the open questions highlighted.

Keywords: AASLD; ACG; AFLD; AGA; APWP; American Association for the Study of Liver Disease; American College of Gastroenterology; American Gastroenterological Association; Asian-Pacific Working Party; CLD; CLDA; CVD; Chinese Liver Disease Association; Clinical practice; EASL; ESPGHAN; European Association for the Study of the Liver; European Society for Pediatric Gastroenterology, Hepatology and Nutrition; GPs; Guidelines; HCC; IASL; IR; Italian Association for the Study of the Liver; LB; LTs; MRFs; MS; NAFLD; NASH; T2D; US; alcoholic fatty liver disease; cardiovascular disease; chronic liver disease; general practitioners; hepatocellular carcinoma; insulin resistance; liver biopsy; liver tests; metabolic risk factors; metabolic syndrome; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; type 2 diabetes; ultrasonography.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biopsy
  • Fatty Liver / diagnosis*
  • Fatty Liver / therapy*
  • Gastroenterology
  • Humans
  • Non-alcoholic Fatty Liver Disease
  • Practice Guidelines as Topic
  • Practice Patterns, Physicians'