Dynamics of the meningeal CD4(+) T-cell repertoire are defined by the cervical lymph nodes and facilitate cognitive task performance in mice

Mol Psychiatry. 2014 May;19(5):531-3. doi: 10.1038/mp.2013.79. Epub 2013 Jun 11.


The traditional view of the central nervous system (CNS) as an immune-privileged organ yielded a longstanding perception of such interactions—as seen for example in multiple sclerosis (MS) , —as intrinsically destructive. This notion is changing with the identification of several homeostatic functions attributable to beneficial T-cell/CNS interaction , for example in hippocampal-dependent learning and stress response paradigms , and in models of neurodegeneration and CNS injury . Here we provide insights into the maintenance, and dynamics of the meningeal T-cell repertoire. We show that meningeal T-cell composition is coupled to the CNS-draining deep cervical lymph nodes (dCLNs), whose surgical removal interrupted the normal flow of meningeal T-cells and resulted in cognitive impairment.

Publication types

  • Letter

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / physiology*
  • Cell Transplantation
  • Cognition / physiology*
  • Infant, Premature
  • Lymph Node Excision
  • Lymph Nodes / physiology*
  • Lymphocyte Count
  • Maze Learning / physiology
  • Meninges / immunology*
  • Mice, Transgenic
  • Monocytes / physiology
  • Neck
  • Neuroimmunomodulation / physiology*
  • Spleen / cytology
  • Spleen / physiopathology