Helicobacter pylori research: historical insights and future directions

Nat Rev Gastroenterol Hepatol. 2013 Aug;10(8):495-500. doi: 10.1038/nrgastro.2013.96. Epub 2013 Jun 11.


Helicobacter pylori leads to chronic gastritis, peptic ulcer disease and gastric cancer. With increasing issues of antibiotic resistance and changing epidemiology of this pathogen, new approaches are needed for effective management. In 1984, Dr Barry Marshall and Dr Robin Warren reported the association of Helicobacter pylori with peptic ulcers in The Lancet--a discovery that earned them the Nobel prize in Physiology or Medicine in 2005--but what progress have we made since then? Here, we have invited three international experts to give their insights into the advances in H. pylori research over the past 30 years and where research should be focused in the future.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Chronic Disease
  • Drug Resistance, Bacterial
  • Gastritis / drug therapy
  • Gastritis / microbiology*
  • Gastroenterology / trends*
  • Helicobacter Infections / drug therapy
  • Helicobacter Infections / microbiology*
  • Helicobacter pylori / growth & development*
  • Humans
  • Microbiological Techniques / trends*
  • Microbiota
  • Peptic Ulcer / drug therapy
  • Peptic Ulcer / microbiology*


  • Anti-Bacterial Agents