Cytomegalovirus pneumonia in hematopoietic stem cell recipients

J Intensive Care Med. 2014 Jul-Aug;29(4):200-12. doi: 10.1177/0885066613476454. Epub 2013 Feb 6.


Cytomegalovirus (CMV) is a frequently encountered infection following hematopoietic cell transplantation, and tissue invasive pneumonia is a dreaded complication of the virus in this population. In this review of CMV pneumonia, we address epidemiology, pathogenesis, diagnostics, current therapy, and strategies to prevent the development of CMV. We also review emerging treatment and prevention options for this challenging disease.

Keywords: CMV pneumonia; antiviral; cytomegalovirus; hematopoietic cell transplant; prevention.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antiviral Agents / therapeutic use
  • Cytomegalovirus Infections / diagnosis
  • Cytomegalovirus Infections / drug therapy
  • Cytomegalovirus Infections / epidemiology
  • Cytomegalovirus Infections / etiology*
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Pneumonia, Viral / diagnosis
  • Pneumonia, Viral / drug therapy
  • Pneumonia, Viral / epidemiology
  • Pneumonia, Viral / etiology*
  • Risk Factors


  • Antiviral Agents