Elucidating the fungal stress response by proteomics

J Proteomics. 2014 Jan 31;97:151-63. doi: 10.1016/j.jprot.2013.06.001. Epub 2013 Jun 10.


Fungal species need to cope with stress, both in the natural environment and during interaction of human- or plant pathogenic fungi with their host. Many regulatory circuits governing the fungal stress response have already been discovered. However, there are still large gaps in the knowledge concerning the changes of the proteome during adaptation to environmental stress conditions. With the application of proteomic methods, particularly 2D-gel and gel-free, LC/MS-based methods, first insights into the composition and dynamic changes of the fungal stress proteome could be obtained. Here, we review the recent proteome data generated for filamentous fungi and yeasts. This article is part of a Special Issue entitled: Trends in Microbial Proteomics.

Keywords: Fungi; Hypoxia; Oxidative stress; Proteome; Stress response.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Physiological / physiology*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Fungi / genetics
  • Fungi / metabolism*
  • Humans
  • Proteome / genetics
  • Proteome / metabolism*
  • Proteomics*
  • Stress, Physiological / physiology*


  • Bacterial Proteins
  • Proteome