The role of CARMA1 in T cells

Crit Rev Immunol. 2013;33(3):219-43. doi: 10.1615/critrevimmunol.2013007056.


Caspase recruitment domain-containing membrane-associated guanylate kinase protein-1 (CARMA1), a member of the membrane associated guanylate kinase (MAGUK) family of kinases, is essential for T lymphocyte activation and proliferation via T-cell receptor (TCR) mediated NF-κB activation. Recent studies suggest a broader role for CARMA1 regulating other T-cell functions as well as a role in non-TCR-mediated signaling pathways important for lymphocyte development and functions. In addition, CARMA1 has been shown to be an important component in the pathogenesis of several human diseases. Thus, comprehensively defining its mechanisms of action and regulation could reveal novel therapeutic targets for T-cell-mediated diseases and lymphoproliferative disorders.

Publication types

  • Review

MeSH terms

  • Animals
  • CARD Signaling Adaptor Proteins / chemistry
  • CARD Signaling Adaptor Proteins / immunology*
  • Guanylate Cyclase / chemistry
  • Guanylate Cyclase / immunology*
  • Humans
  • Receptors, Antigen, T-Cell / immunology
  • Signal Transduction
  • T-Lymphocytes / immunology*


  • CARD Signaling Adaptor Proteins
  • Receptors, Antigen, T-Cell
  • Guanylate Cyclase