The H2A/H2B-like histone-fold domain proteins at the crossroad between chromatin and different DNA metabolisms

Transcription. 2013 May-Jun;4(3):114-9. doi: 10.4161/trns.25002. Epub 2013 May 16.

Abstract

Core histones are the building block of chromatin and among the most highly conserved proteins in eukaryotes. The related "deviant" histones share the histone-fold domain, and serve various roles in DNA metabolism. We provide here a structural and functional outlook of H2A/H2B-like deviant histones in transcription, replication and remodeling.

Keywords: H2A/H2B; NC2; NF-Y; TAF4/12; chromatin; chromatin remodeling complex; histone-fold; nucleosome; posttranslational modifications; transcription factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • CCAAT-Binding Factor / metabolism
  • Chromatin / metabolism*
  • DNA / metabolism*
  • DNA Replication
  • Histones / chemistry
  • Histones / metabolism*
  • Humans
  • Molecular Sequence Data
  • Nucleosomes / metabolism
  • Promoter Regions, Genetic
  • Protein Structure, Tertiary
  • Saccharomyces cerevisiae / metabolism
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Transcription Factors / metabolism
  • Transcription, Genetic
  • Xenopus / metabolism

Substances

  • CCAAT-Binding Factor
  • Chromatin
  • Histones
  • Nucleosomes
  • Transcription Factors
  • DNA