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. 2013 Jun 11;2013:bat037.
doi: 10.1093/database/bat037. Print 2013.

FSRD: Fungal Stress Response Database

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Free PMC article

FSRD: Fungal Stress Response Database

Zsolt Karányi et al. Database (Oxford). .
Free PMC article

Abstract

Adaptation to different types of environmental stress is a common part of life for today's fungi. A deeper understanding of the organization, regulation and evolution of fungal stress response systems may lead to the development of novel antifungal drugs and technologies or the engineering of industrial strains with elevated stress tolerance. Here we present the Fungal Stress Response Database (http://internal.med.unideb.hu/fsrd) aimed to stimulate further research on stress biology of fungi. The database incorporates 1985 fungal stress response proteins with verified physiological function(s) and their orthologs identified and annotated in 28 species including human and plant pathogens, as well as important industrial fungi. The database will be extended continuously to cover other fully sequenced fungal species. Our database, as a starting point for future stress research, facilitates the analysis of literature data on stress and the identification of ortholog groups of stress response proteins in newly sequenced fungal genomes. Database URL: http://internal.med.unideb.hu/fsrd

Figures

Figure 1.
Figure 1.
The number of stress-related articles published on fungi from 2000. Columns show the annual number of fungal stress research articles; closed symbols connected by lines represent the number of articles grouped according to selected types of stress (oxidative stress, osmotic stress, nutrients stress, DNA damage, heat shock and unfolded protein response ‘UPR’).
Figure 2.
Figure 2.
Summary of the construction of the Fungal Stress Response Database. Starter database was constructed from the stress response proteins, which were collected from AmiGO and PubMed databases. Protein sequences in the starter database were used to identify the orthologs in the proteome databases via homology search by the Inparanoid 4.1 software.
Figure 3.
Figure 3.
The fungal stress response database entry side.

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