The oxidative and antioxidative status of simple febrile seizure patients

J Pak Med Assoc. 2013 May;63(5):594-7.


Objective: To evaluate the oxidative status following a seizure in children experiencing a simple febrile seizure.

Methods: The cross-sectional study was conducted at Harran University, Turkey, between January and September 2011. It comprised 32 paediatric patients who, within the preceding 8 hours, had experienced a seizure due to upper respiratory tract infection and had been diagnosed with simple febrile seizure, and 30 healthy children as the control group. Blood was taken from the patients 8 hours after the seizure. Total oxidant level and Total anti-oxidant level were measured according to the Erel technique and the oxidative stress index was calculated. Data was analysed using SPSS 11.5.

Results: The mean values of the total oxidant level and the oxidative stress index of the cases were found to be significantly high compared to the controls and the total anti-oxidant level was found to be significantly low (p < 0.01, p < 0.01, p < 0.03 respectively).

Conclusion: The increased total oxidant level and decreased total anti-oxidant level resulting in increased oxidative stress associated with febrile seizure patients may increase the risk of experiencing febrile seizures.

MeSH terms

  • Antioxidants / metabolism*
  • Case-Control Studies
  • Child, Preschool
  • Cross-Sectional Studies
  • Female
  • Humans
  • Infant
  • Male
  • Otitis / complications
  • Oxidants / blood*
  • Seizures, Febrile / blood*
  • Seizures, Febrile / etiology
  • Tonsillitis / complications


  • Antioxidants
  • Oxidants