Various cyclization scaffolds by a truly Ugi 4-CR

Org Biomol Chem. 2013 Aug 7;11(29):4792-6. doi: 10.1039/c3ob40523k. Epub 2013 Jun 13.


Efficient access to a large chemical space based on new scaffolds with defined 3D conformations and highly variable in the side chains is needed to find novel functional materials. Four heterocyclic scaffolds based on a four component Ugi reaction of α-amino acids, oxo components, isocyanides and primary or secondary amines suitably functionalized are described. A handful of examples are described for each scaffold.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry*
  • Amino Acids / chemistry*
  • Cyanides / chemistry*
  • Cyclization
  • Ketones / chemistry*
  • Models, Molecular
  • Molecular Conformation
  • Pyrrolidines / chemical synthesis*
  • Pyrrolidines / chemistry


  • Amines
  • Amino Acids
  • Cyanides
  • Ketones
  • Pyrrolidines