Neonatal sepsis due to coagulase-negative staphylococci

Clin Dev Immunol. 2013;2013:586076. doi: 10.1155/2013/586076. Epub 2013 May 22.

Abstract

Neonates, especially those born prematurely, are at high risk of morbidity and mortality from sepsis. Multiple factors, including prematurity, invasive life-saving medical interventions, and immaturity of the innate immune system, put these infants at greater risk of developing infection. Although advanced neonatal care enables us to save even the most preterm neonates, the very interventions sustaining those who are hospitalized concurrently expose them to serious infections due to common nosocomial pathogens, particularly coagulase-negative staphylococci bacteria (CoNS). Moreover, the health burden from infection in these infants remains unacceptably high despite continuing efforts. In this paper, we review the epidemiology, immunological risk factors, diagnosis, prevention, treatment, and outcomes of neonatal infection due to the predominant neonatal pathogen CoNS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Coagulase
  • Humans
  • Infant, Newborn
  • Infant, Premature / immunology*
  • Infant, Premature, Diseases / epidemiology
  • Infant, Premature, Diseases / immunology*
  • Infant, Premature, Diseases / microbiology
  • Infant, Premature, Diseases / therapy
  • Intensive Care Units, Neonatal
  • Sepsis / epidemiology
  • Sepsis / immunology*
  • Sepsis / microbiology
  • Sepsis / therapy
  • Staphylococcal Infections / epidemiology
  • Staphylococcal Infections / immunology*
  • Staphylococcal Infections / microbiology
  • Staphylococcal Infections / therapy
  • Staphylococcus / drug effects
  • Staphylococcus / growth & development
  • Staphylococcus / immunology
  • Staphylococcus / pathogenicity*
  • Virulence

Substances

  • Anti-Bacterial Agents
  • Coagulase