Thwarting galectin-induced immunosuppression in breast cancer

Oncoimmunology. 2013 May 1;2(5):e24077. doi: 10.4161/onci.24077.


Novel therapeutic strategies are needed to counteract breast cancer-associated immunosuppression. Silencing the expression of galectin-1 in a breast carcinoma model inhibited tumor growth and prevented lung metastasis by reducing the frequency and immunosuppressive activity of CD4+CD25+ FOXP3+ regulatory T cells.

Keywords: Galectin-1; breast cancer; immune escape; metastasis; regulatory T cell.