Attenuated measles virus used as an oncolytic virus activates myeloid and plasmacytoid dendritic cells

Oncoimmunology. 2013 May 1;2(5):e24212. doi: 10.4161/onci.24212.


Attenuated measles viruses (MV) are assessed in clinical trials for their capacity to preferentially infect and kill tumor cells. We recently showed that MV-infected tumor cells are able to activate tumor antigen cross-presentation by myeloid and plasmacytoid dendritic cells. Thus, MV-based antitumor virotherapy may stimulate antitumor immune response.

Keywords: cytotoxic CD8+ T cell; measles virus vaccine; myeloid DC; oncolytic virus; plasmacytoid DC; tumor antigen.